Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-diabetic activity of aqueous extract of Fructus Ligustri Lucidi in a rat model of type 2 diabetes

Juan Lv¹, Lanxiu Cao² , Rui Zhang³, Pengfei Wei⁴

¹Department of Traditional Chinese Medicine; ²Department of Prescription, Basic Medical College, Shanxi University of Traditional Chinese Medicine, Xianyang, 712046; ⁴Department of Diabetes, The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, 4Department of Radiotherapy, The First Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Xianyang, 712000, China.

For correspondence:- Lanxiu Cao Email: lanxiucaodoczhej@126.com

Accepted: 26 June 2018 Published: 28 July 2018

Citation: Lv J, Cao L, Zhang R, Wei P. Anti-diabetic activity of aqueous extract of Fructus Ligustri Lucidi in a rat model of type 2 diabetes. Trop J Pharm Res 2018; 17(7):1373-1377 doi: 10.4314/tjpr.v17i7.21

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the anti-diabetic activity of an aqueous extract of Fructus Ligustri Lucidi (FLL) in a rat model of type 2 diabetes (T2D).

Methods: Body weight (BW), food intake (FI), fasting blood glucose (FBG), glucose tolerance testing and insulin tolerance testing were used to determine the anti-diabetic activity of an aqueous extract of Fructus Ligustri Lucidi (FLL) in a rat model of streptozotocin-induced T2D. Anti-oxidant activity and oxidative stress were assessed by superoxide dismutase (SOD) and malondialdehyde (MDA) analyses, respectively.

Results: Following FLL extract treatment, diabetic rat BW increased, while FI and FBG levels decreased. FLL extract increased glucose tolerance and decreased insulin tolerance. Following treatment with 300 and 600 mg/kg FLL extract, MDA levels reached 13.5 ± 0.9 nmol/ml and 13.8 ± 1.1 nmol/ml, respectively. Compared to MDA levels of 19.5 ± 1.1 nmol/ml in diabetic control group, MDA levels was decreased by 30.8 % and 29.0 % after the treatment with 300 and 600 mg/kg FLL extract, respectively, indicating alleviated oxidative stress.

Conclusion: The results show that aqueous FLL extract has the potential to alleviate T2D, resulting in reduced FI and FBG, and increased BW. The anti-diabetic activity of FLL extract on T2D may be relevant to reduced oxidative stress burden.

Keywords: Fructus Ligustri Lucidi, Type 2 diabetes, Anti-oxidant activity, Glucose tolerance, Insulin tolerance, Anxiety-like behaviour